Osh - ‘Kyzyl-Art’ border check-point - Karakul Lake - Murghab (440 km, 9-10 hrs). Breakfast at the hotel. Start of travelling along Pamir Highway. Transfer to Kyrgyz-Tajik border ‘Kyzyl-Art’ via the Kyzyl-Art pass (4,280 m). Cross the border at ‘Kyzyl-Art’ border check point and continue to the high-altitude Karakul Lake (3,914 m) - the largest lake in Tajikistan and one of the highest in Central Asia, surrounded by mountain peaks. Lunch en-route. Drive over the Akbaital Pass (4,655 m), which is the highest road pass in the CIS and highest point of the M41 highway. Arrival in Murghab (3,600 m) - the highest alpine town in Tajikistan and the whole Central Asia. Overnight at the hotel.